Obesity, Insulin Rejection, and Obesity:

Diabetes is a major global health concern. Besides the commonly understood lifestyle implications, it is important to understand certain populations propensity or vulnerability to these diseases in order to more effectively combat them. Obesity, which often starts at childhood and can be dictated genetically through triggers, often leads to insulin rejection, which if left unchecked can lead to full-blown diabetes. Once diabetes becomes visible in an individual, the care and maintenance of that persons health becomes much more difficult. If the genetic, environmental, and behavioral warning signs are heeded, these conditions are much less likely to affect the populations who may be most vulnerable. Certain triggers, both genetic and environmental have been identified in mice that suggest every human has an equal lot in understanding their risk factors for these conditions and mitigating these risks as best as possible.

If these triggers and environmental factors are caught and reversed early, there is hope of reducing the prevalence of these conditions throughout the world.

References

Bacquer, Olivier; Emmanuel Petroulakis, Sabina Paglialunga, Francis Poulin, Denis Richard,

Katherine Cianflone, and Nahum Sonenberg. “Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2.” Journal of Clinical Investigation, Vol. 111, No. 2, February, 2007. pp. 387-396.

Lewis a. Barness, Lewis a.; John M. Opitz, and Enid Gilbert-Barness. “Obesity: Genetic, molecular, and environmental aspects.” American Journal of Medical Genetics Part a. Vol. 143A, No. 24, December, 2007. pp. 3016 — 3034.

Jhingan, Ashok. Diet and Diabetes. New Dheli: Concept Publishing, 2005.

Keller, Ulrich. “From obesity to diabetes.” International ISFE Symposium No. 15, Madrid,

Spain,.

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